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Is Iron Harmful to People with Gout and Arthritis?

By September 14, 2022No Comments3 min read

Iron homeostasis has been linked to painful inflammatory conditions such as Gout and Rheumatoid Arthritis in study after study. Surprisingly, both iron overload and anemia appear to have a significant impact on uric acid and inflammatory cytokines in rheumatic patients.

 

Hereditary hemochromatosis causes hemochromatosis (iron overload) caused by genes inherited from your parents. This condition can also be caused by conditions such as liver disease or repeated blood transfusions. The body’s natural excretory capacity cannot be increased. As a result, anyone suffering from iron overload will continue to store and accumulate the excess. These deposits accumulate in the joints, the heart, the liver, and even the testicles, where they can cause damage. Many people live with this condition unknowingly, with no signs or symptoms. Others may suffer greatly as a result of more severe symptoms such as fatigue, joint pain, sexual dysfunction, diabetes, liver cirrhosis, and even heart failure. Women accumulate iron more slowly than men because they excrete more iron during menstruation and breastfeeding. This can cause symptoms of organ damage caused by iron overload to appear 10 years later in women than in men.

 

Iron deficiency, on the other hand, appears to play an important role in our body’s inflammatory response. To ensure oxygen delivery, metabolism, and redox management while protecting us from toxins that cause cellular damage and death, iron levels must be tightly controlled. This delicate balance is directly related to cell health, as well as inflammatory and infection responses. Iron status has a significant impact on chronic inflammatory diseases.

 

Anemia can also be caused by chronic inflammation and inflammatory diseases. Chronic and long-term conditions can impair the body’s ability to produce healthy red blood cells. The second most common cause, after iron deficiency anemia, is anemia of inflammation. Chronic infections such as tuberculosis, autoimmune conditions or diseases with inflammation, and certain types of cancer such as Hodgkin’s, lung, and breast cancer are all known to cause anemia of inflammation. This condition’s symptoms can be difficult to distinguish from the primary condition that is causing the anemia. As a secondary condition, it frequently goes undetected, undiagnosed, and thus untreated.

 

While Anemia and Hemochromatosis have been identified as direct risk factors for Gout, Rheumatism, and other chronic conditions such as Diabetes and Obesity, the biological mechanisms remain unknown.

 

Here are a few facts we do know:

  • Elevated uric acid levels are linked to elevated iron levels.
  • Anemia has recently been identified as a new risk factor for Gout.
  • Cytokines cause iron traffic to be diverted under chronic inflammatory conditions.
  • In rheumatic diseases, iron homeostasis is disrupted, with decreased metal in response to inflammation.
  • Iron supplementation may have a negative impact on the activity of the chronic conditions involved.
  • Iron absorption is improved by vitamin C. As a result, Vitamin C can bind to Uric Acid in the blood, making it difficult to excrete it as needed.

 

 

Learn More:

Cytokine-mediated regulation of iron transport in human monocytic cells

Connection With High Iron in Blood for Gout

Iron homoeostasis in rheumatic disease

Anemia and the onset of gout in a population-based cohort of adults: Atherosclerosis Risk in Communities study