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Gout Diagnosis

Is gout a genetic or lifestyle disease

By August 9, 2022August 10th, 2022No Comments5 min read

Although genetics and genetic mutations can play a role in disease, poor nutrition and a sedentary lifestyle can significantly increase the risk. Gout is a common condition, but it affects some populations more than others. Gout, for example, affects 1% of people of Asian ancestry, 3% to 4% of people of European ancestry, and 6 to 8% of Indigenous (native) Taiwanese peoples and Mori from New Zealand.

Urate accumulates in the kidneys and forms kidney stones in about 15% of people with gout. As the condition worsens, urate crystals can form nodules called tophus under the skin or in other soft tissue (plural: tophi). These tophi frequently appear on the hands, elbows, or feet. Tophi do not usually cause pain, but they can become inflamed, infected, or ooze fluid if they become inflamed, infected, or ooze fluid. Tophi, depending on their location, can obstruct movements such as walking or gripping objects.

Many people who have gout also have other health problems. The majority of those affected have high blood pressure (hypertension), chronic kidney disease, or obesity. Some have diabetes, heart disease, or a stroke history. It is unclear whether gout increases a person’s risk for these conditions, whether the conditions cause gout to develop, or whether both situations occur to influence disease.

Gout is caused by both hereditary and environmental causes. Some of the risk factors for this disorder have been identified via research, while others remain unclear. Hyperuricemia is the most important risk factor for getting gout. Gout affects about one-quarter of those who have hyperuricemia. It is unknown why other people with hyperuricemia do not get gout.

Several large investigations have discovered dozens of genes that contribute to the development of gout. Multiple genetic alterations, each with a minor impact, are likely to contribute to an increased risk of having this condition. The majority of known genes are involved in the transfer of urate, which is a byproduct of regular metabolic processes. Many gout-associated genes are involved in either excreting urate through the urine or reabsorbing it into the bloodstream if more is required in the body. Other linked genes are involved in the transport or breakdown of sugars, as well as the transport of other small molecules. Some related genes’ functions are unknown. Two genes, SLC2A9 and ABCG2, appear to have the biggest influence on urate levels of all those investigated.

 

The SLC2A9 gene codes for a protein that is present mostly in the kidneys and plays a function in regulating urate levels in the body. This protein aids in the reabsorption of urate into the bloodstream or its excretion in the urine. Changes in the SLC2A9 gene that cause hyperuricemia increase urate reabsorption into the circulation and reduce urate excretion in the urine.

The ABCG2 gene codes for a protein that aids in the release of urate into the stomach so that it can be eliminated from the body. The ability of the ABCG2 protein to release urate into the gut is reduced by genetic alterations in the ABCG2 gene that can result in hyperuricemia.

 

Non Genetic variables are thought to play a role in gout, especially through causing flares. These factors frequently raise urate levels in the body. Consuming meals and beverages high in purine molecules, such as red meat, shellfish, dry beans, alcohol, and sugar-sweetened beverages, might result in an increase in urate. Purines are broken down to become urate, which can cause hyperuricemia and contribute to gout in some people. Gout risk increases with age as well. Women are more vulnerable after menopause. Following menopause, the hormone estrogen, which aids in the removal of urate from the body, decreases, causing older women to have higher urate levels and an increased chance of getting gout.

Because several genetic and environmental factors appear to be involved, the inheritance pattern of gout is uncertain. Having a close relative with gout, on the other hand, increases a person’s likelihood of developing the ailment.

It is vital to highlight that dying cells contribute the most uric acid, approximately 70%. This is a matter for concern not only because dying cells produce extra uric acid, but also because of the dangers that significant cellular die-off poses to your overall health. While genetics can play a part, your diet and lifestyle habits have a direct impact on the health of your cells. This is most likely the more crucial region to concentrate on. Genetic recognition and information will not help you solve your gout problems, but the health of your cells will!